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For patients undergoing cardiopulmonary bypass in the course of coronary artery bypass graft, there is a high risk of perioperative blood loss and the need for blood transfusion. In order to reduce this risk, aprotinin is used. In other complicated surgeries as well like liver or heart or heart- lung transplantation or total hip replacement or peripheral vascular surgery, this medicine is used to reduce bleeding and the need of blood transfusion. Only preliminary studies have been done so far to assess the efficacy in these indicators and further studies are still to be carried out.

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