A new class of antibiotics related to macrolides is called ketolides. Ketek belongs to one of a group of ketolides’s medicines. Bacteria cause infections and antibiotics stop the growth of bacteria. Ketek is a medicine that is active against bacteria. It is used by adults and young people of about 12 years of age and above. Patients with long-standing breathing difficulties and pneumonia due to chest infections use Ketek. Infections of the sinuses and throat can be cured by Ketek.

The first ketolide antibiotic to enter the clinical use is telithromycin-sold under the brand name Ketek It is semi-synthetic erythromycin derivative, marketed under the brand name Ketek and treats mild respiratory infections. To achieve better acid-stability the carbon present at the position 6 is methylated.

It works by interfering the protein synthesis of the bacteria, hence prevents them from growing by blocking the growth of their polypeptide chain. Telithromycin can be taken orally while remaining protected from gastric acids, as unlike erythromycin, telithromycin is acid-stable. It is actively transported to the site of infection because of the high concentration in phagocytes. Huge quantity of telithromycin is released during active phagocytosis. The concentration of telithromycin in the plasma is much lower than in the tissues. The rise of microbial resistance to existing macrolides makes the role of telithromycin more relevant and against macrolide-resistant Streptococcus pneumonia; it has proven to be effective. A small portion of telithromycin is excreted into the urine; bile is the major elimination route but it is mainly metabolized in the liver. Half-life of telithromycin is approximately 10 hours. In bile and urine almost one third is excreted unchanged, however mostly from the bile route.

Avoid Ketek if you are suffering from a muscle weakness disease called myasthenia gravis or if you are taking medicines to control blood levels of cholesterol or other lipids. Talk to your doctor if you are allergic to any of the ingredients of Ketek or to any of the macrolide antibiotics or sensitive to telithromycin. While taking Ketek in the past if you or someone in your family had jaundice and/or hepatitis or long QT syndrome- an abnormality of electrocardiogram (ECG), contact a health care professional. Don’t take substances containing an anti fungal treatment- ketoconazole and a medicine called protease inhibitor used for HIV treatment.

Ketek should be taken as is prescribed by the health professional. Directions on your prescription label have to be followed and dose should not be taken in larger quantity but as is recommended. It can be taken with or without food with a full glass of water. Take it once a day and at the same time each day. Don’t discontinue the recommended dosage even if you feel better.  As soon as you remember that you have missed a dose, take it. However do not take the missed dose if it is the time for your next dose.

Ketek does not cause overdose symptoms but seek medical attention if you have taken an overdose.

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