Fen-Phen is a weight loss pill. It is a combination drug containing fenfluramine and phentermine. Fenfluramine is nearly similar to other anti obesity drug dexfenfluramine, sold with name Redux. Whereas Phentermine was also sold with many brand names including Phentrol for treatment of obesity. The combination was launched in the market as a miracle drug to reduce obesity. It was withdrawn from U.S. market in 1997 due to its alleged link with heart valve diseases.

Phentermine was approved in 1959 by the United States Food & Drug Administration. It was approved to be used as anti obesity drug. Fenfluramine was approved by the FDA to be used as a drug to reduce obesity in 1973.  It was approved to be used as a part of a anti obesity program containing diet and exercise. Both the drugs were approved for short-term use only.

Uses of Fen-Phen

The Fen-Phen is anti obesity drug. It is a combination of fenfluramine and phentermine. These two drugs were used to treat obesity. A combination of these drugs is said to be more effective in weight reduction. The Fen-Phen is used along with diet, exercise and behavior modification.

Precautions before using Fen-Phen

Fen-Phen is a drug used for weight reduction. One should take following precautions while using this drug.

  • Phentermine hydrochloride is approved for short-term use only. It is used for mono therapy, whereas Fenfluramine is also approved for short-term use along with diet and exercise. Safety of this combination has not been proved, thus it should not be used without prescription of any medical practitioner.
  • Fenfluramine has been linked with valvular heart diseases, thus consult your doctor before using Fen-Phen.
  • Do not use this drug if you are suffering from any type of heart disease.
  • Phentermine has also been linked to heart disease; do not use this drug without doctors advise.
  • This drug starts showing effective results after few weeks of use. Thus, patients should not exceed the recommended dose if its effect does not show in the first few days of use.
  • When a patient develops tolerance to the anorectic effect, doses should not be exceeded, rather, they should stop taking this medicine.
  • Phentermine hydrochloride may decrease the hypotensive effect of guanethidine, thus both should not be used at a time.
  • Monoamine oxidase inhibitors (MAOIs) may increase the response to the anti-obesity drug. Thus one should use these medicine at least after a interval of 2 weeks.
  • If a patient develops symptoms of any heart valve damage, he should immediately seek medical assistance.
  • Fenfluramine has been linked to increased risk of Primary Pulmonary Hypertension, thus it should only be used if prescribed by a certified medical practitioner.
  • It should not be used in children, as it could yield fatal side effects.
  • Elderly people should use it with caution.
  • Patients may regain weight after they stop use of Fen-Phen. They should remain in touch with their doctor and should continue with diet and exercise as asked by their doctor.

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