Dexfenfluramine is a weight loss pill marketed with the brand name Redux.  It is a serotonin reuptake inhibitor and releasing agent. Redux is actually dexfenfluramine hydrochloride. U.S. Food and Drug administration approved it in 1990 to be used for weight loss. Later it was related to several cardio vascular diseases including primary pulmonary hypertension and its approval was cancelled in 1997. 

Structural Formula

Dexfenfluramine is a serotonin reuptake inhibitor and releasing agent. Its Chemical name is ethyl({1-[3-(trifluoromethyl)phenyl]propan-2-yl})amine, while Redux or dexfenfluramine hydrochloride is called (S)-N-ethyl-alpha-methyl-3-(trifluoromethyl) benzeneethanamine hydrochloride. Its chemical Formula is C12H16F3N and its formula in hydrochloride form is C12H16F3N·HCl. Dexfenfluramine has a molecular weight of 231.2573, while dexfenfluramine hydrochloride has a molecular weight of 267.7.

Dexfenfluramine hydrochloride is crystalline powder in white to off- white color. It has lactose, gelatin capsule, cornstarch, microcrystalline cellulose, talc, titanium dioxide, magnesium stearate, colloidal silicon dioxide, and edible ink as inactive ingredients. It can be easily soluble in water, chloroform, methanol and alcohol.

Uses of Dexfenfluramine

Dexfenfluramine or Redux is a weight loss drug. It is used for treatment of obesity. It helps to reduce weight if taken along with a low calorie diet. This drug has been removed from market in U.S. by FDA due to safety concerns. It has been linked with heart problems including primary pulmonary hypertension.

It is an oral medicine taken twice a day with meal. The dosage should be based on prescription of a certified medical practitioner.


Precautions before using Dexfenfluramine

  • Consult your doctor before taking this medicine if you have any type of  heart disease.
  • It’s advisable to tell your doctor if you have high blood pressure before going for this medicine.
  • Consult your doctor before taking this medicine if you are suffering from any type of lung diseases.
  • If you are suffering from pulmonary hypertension, it is advisable to avoid use of this medicine.
  • If you are suffering from breathing problems consult your doctor before using this medicine.
  • Other condition to discuss with your doctor is thyroid problems.
  • You should consult your doctor before using this medicine if you have Glaucoma.
  • If you have allergy from any of its ingredients or any other type of allergy, tell your doctor.
  • Consult your doctor before using it, if you have any liver disease.
  • Do not take or at least have control consumption of alcohol while using this drug.
  • Avoid activities needing high level of alertness while using this drug as it could cause drowsiness.
  • Avoid using this drug, if you are pregnant, trying to have a baby or breast-feeding. Tell your doctor if you get pregnant while using this drug.
  • Be cautious while using this drug if you are an elderly person.
  • If you develop nausea or vomiting while using, immediately consult your doctor.
  • It should not be used with other drugs.
  • It has not been known that it is safe for children or not. It is advisable to avoid its use in children.

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