Boniva is brand name for ibandronate. It belongs to bisphosphonates group of medicines. It is used for treatment of osteoporosis in women after menopause. It also prevents osteoporosis by affecting the bone formation and breakdown cycle. It slows down the process of bone loss and alongside increases bone mass. This alteration prevents bone fractures. Though it is mainly used to treat osteoporosis, it is also used for other purposes as well.

Structural Formula

Boniva is mainly ibandronate sodium and contains nitrogen. It belongs to isphosphonate group of medicines and has properties of osteoclast-mediated bone resorption. The chemical name of ibandronate sodium is 3-(N-methyl-N-pentyl) amino-1-hydroxypropane-1,1diphosphonic acid. It is monosodium salt, monohydrate and its chemical formula is C9H22NO7P2Na•H2O. It has molecular weight of 359.24.

Ibandronate sodium has the following structural formula:

It is a powder in white or off-white color. It can be freely dissolved in water and is insoluble inorganic solvents.

Boniva is an oral drug and each 2.5 mg tablet of Boniva contains 2.813 mg ibandronate monosodium monohydrate and 150 mg tablet contains 168.75 mg ibandronate monosodium monohydrate. Boniva also contains lactose monohydrate, povidone, microcrystalline cellulose, crospovidone, purified stearic acid, colloidal silicon dioxide, and purified water as inactive ingredients. The film on the tablet contains hypromellose, titanium dioxide, talc, polyethylene glycol 6000, and purified water.

Uses of Boniva

Boniva is used to treat or prevent osteoporosis in woman after menopause. In most women osteoporosis develops after menopause due to hormonal changes. These hormonal changes affect bone formation and breakdown cycle, thus triggering advent of osteoporosis.

There are no evident proof of its interaction with other drugs but it is advisable to consult a doctor before using Boniva, if you are on other medications as well. Bisphosphonates’ adverse effect on pregnant women and nursing mothers is not known, but its better to take caution. Consult your doctor before using it while pregnant or breast-feeding.

Precaution before using Boniva

  • After use of Boniva the user need to sit upright for at least 1 hour otherwise it can cause problems in the stomach or esophagus. It is advisable to avoid it if you are not able to sit upright or stand for long time.
  • It should be taken early in the morning with a glass full of plain water.
  • If you have cancer or have been treated with chemotherapy, radiation, or steroids, you are more prone to develop osteonecrosis of jaw after using Boniva. Consult your doctor in such a condition, before taking Boniva.
  • Other conditions such as blood clotting disorders, anemia, and pre-existing dental problems also increase chances of developing osteonecrosis of jaw after using Boniva.
  • If you develop problems such as jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums after using Boniva, immediately consult your doctor as it could be a sign of osteonecrosis of jaw.
  • Before taking Boniva tell your doctor if following conditions exit so that he can treat you accordingly.

♦ If you have a vitamin D deficiency

♦ If you are suffering from any kidney disease

♦ If you have any ulcer in stomach or esophagus

♦ If you face trouble while swallowing

  • Boniva is a FDA pregnancy category C drug. Its adverse effects in pregnant or breast-feeding mothers are not known. It is advisable to consult your doctor before taking Boniva if you are pregnant, planning to have a baby or breast-feeding a baby.

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