Pfizer faced a blow as a jury verdict came against Pfizer Inc.’s Warner-Lambert Co. related to diabetes drug Rezulin in 2001. The diabetic drug Rezulin was recalled in March 2000.

Rezulin is an oral anti hyperglycemic drug. It contains Troglitazone as its main active ingredient. Rezulin is used for management of type II diabetes or Diabetes mellitus. It is non-insulin dependant type of diabetes. Rezulin decreases insulin resistance. It makes muscles and adipose tissues more responsive to insulin. It helps to improve body respond to insulin. It controls blood sugar level by reducing sugar produced in liver. Troglitazone has been withdrawn from the U.S. market in 2000.

It was linked with severe side effects with starting of its use. FDA was continuously reviewing this drug for many severe side effects associated with it. It was linked with many severe side effects. Many of the patients using this drug suffered jaundice, fatigue, abdominal pain, weight loss, nausea and vomiting, loss of appetite, back pain and dark urine, which are symptoms of acute liver damage. It had caused liver failure in many patients. They needed to have a liver transplant. It is also said to cause coma and even death in some patients. It is also linked with heart problems.

Liver failure was so evidently prevalent amongst patients using Rezulin, that it could not be ignored. Patients using this drug were regularly being monitored for any liver damage. Its use not only lead to liver damages, but was capable of fatally worsen the existing liver problems. It was said that patients using this drug were at 1200 time higher risk to have a liver failure than non-users of the drug. After issuing many safety alerts related to this drug time to time FDA finally decided to withdraw it from the market on 21st March 2000.

The jury verdict came from a jury in Corpus Christi, Texas. The jury came with an order to pay $43 million in damages to a woman, who suffered severe liver damage due to Rezulin. Later the company agreed to pay $30 million to settle the case. This verdict had proved that Rezulin is a dangerous drug. It had set an example for other drug making companies, which are involved in production of drugs being linked to severe side effects. This is going to be a lesson to pharmaceutical companies who disregard the fatal risks of hastening a medication to market.

Pfizer Inc, which acquired Warner-Lambert, the manufacturer of Rezulin was marred with numerous lawsuits related to side effects of Rezulin. Later in 2004 Pfizer settled around 3500 product liability lawsuits, which were consolidated for $750 million.

Though the Rezulin was recalled on 21st March 2000 by its manufacturer Warner-Lambert on insistence of FDA, it has been left scars of harm on many patients who had used it. At the time of its recall experts opined that it already had caused 90 cases of liver failure, including 63 deaths. In 1999 FDA decided to keep Rezulin in the market, even after it was linked to liver damages including liver failure. It corrected its previous decision by recalling the diabetic drug Rezulin in March 2000.